I don't think anyone wants a reader to be completely lost - certainly not to the point of giving up - but there's something to be said for a book that isn't instantly disposable, that rewards a second reading.
At one point I intended to write precursor and sequel novels, about the establishment of the Web and its next evolution, but I am very unlikely to now; they would take place in a different universe.
Naturally, the reader has access only to the events I show and the way I show them, but as has been said, there's generally a good deal of ambiguity in that presentation.
Well, it's an adventure story, and a Bildungsroman, of course, but there was also the intention to describe a culture that had been seen in rather narrow terms.
The cynical part of the answer is that I expect to see a good deal more space opera, set far enough in the future as to be disconnected from contemporary issues.
The people who don't like it tend to dislike it intensely. That's unfortunate, but not surprising when one deliberately goes against audience expectations.
There are readers who want every point to be clearly and unambiguously set forth, and there are those who want to pry ideas and meanings out for themselves.
People tell me they laughed hard enough to wake their spouses, that they've given away numerous copies to friends, and that it's the one Trek book they'll give to people they wouldn't expect to like others.